Step 1- Choose the Default layout. This is done by using the Esc key -> Edit mode -> Default -> Save and exit.
Step 2- You need to lock the interfaces. If you don't, you'll be able to drag them around still. Click the Lock on the Menu tab. (Circled below)
Step 3- Now to turn off all of the hotkeys for bringing up tabs. This is done by Esc->Controls.
Step 4- Clear all of the hotkeys for menus. Simply hover over and hit the X to clear it.